Actinic keratosis is a pre-cancerous area of thick, scaly, or crusty skin. Actinic keratosis is a disorder of epidermal keratinocytes that is induced by ultraviolet (UV) light exposure. These growths are more common in fair-skinned people and those who are frequently in the sun. They are believed to form when skin gets damaged by UV radiation from the sun or indoor tanning beds, usually over the course of decades. Given their pre-cancerous nature, if left untreated, they may turn into a type of skin cancer called squamous cell carcinoma. Untreated lesions have up to a 20% risk of progression to squamous cell carcinoma, so treatment by a dermatologist is recommended.
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Actinic keratoses 称为老年性角化病或日光性角化病,常与长期日晒有关,常表现为受光照部位的粗糙红色斑块。及早发现并及时治疗非常重要,因为若不治疗,可能进展为皮肤癌。 Actinic keratoses, also known as senile keratoses or solar keratoses, are benign intra-epithelial neoplasms commonly evaluated by dermatologists. Often associated with chronic sun exposure, individuals with actinic keratosis may present with irregular, red, scaly papules or plaques on sun-exposed regions of the body. Timely detection and implementation of a treatment plan are crucial since actinic keratosis can potentially progress into invasive squamous cell carcinoma.
Actinic keratoses 是皮肤细胞的异常增生,具有转化为癌症的风险。它们常出现在长期日晒的皮肤上,表现为平坦的斑点、凸起的肿块或粗糙的斑块,颜色多为淡红色。 在早期,触诊往往比目视检查更能发现它们。 Actinic keratoses are dysplastic proliferations of keratinocytes with potential for malignant transformation. Clinically, actinic keratoses present as macules, papules, or hyperkeratotic plaques with an erythematous background that occur on photoexposed areas. At initial stages, they may be better identified by palpation rather than by visual inspection.
光化性角化病的特征表现为厚实、鳞屑或结痂的斑块,通常感觉干燥或粗糙。病灶大小一般在 2 到 6 毫米之间,直径可达数厘米。值得注意的是,在肉眼尚未清晰看到病变前,常可通过触摸感知,其质地有时类似砂纸。
阳光照射与光化性角化病之间存在因果关系。病变常出现在曾晒伤的皮肤以及长期日晒的部位,如面部、耳朵、颈部、头皮、胸部、手背、前臂或唇部。大多数患者同时出现多个病灶。
如果临床检查结果不典型,且仅凭检查无法排除原位或浸润性鳞状细胞癌(SCC)的可能性,则应考虑活检或切除。
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